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Clinical Pharmacokinetics|January 10, 2024
Safety and Pharmacokinetics of HRS-2261, a P2X3 Receptor Antagonist, in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Phase 1 StudyYuru Fan, Xuan Zhang, Qin Zhang, et al.International Immunopharmacology|January 13, 2024
Extracellular CIRP induces abnormal activation of fibroblast-like synoviocytes from patients with RA via the TLR4-mediated HDAC3 pathwaysFeng Yao, Yingjie Zhao, Qiuxia Yu, et al.International Immunopharmacology|December 3, 2025
G3BP2 facilitates abnormal activation of fibroblast-like synoviocytes through p53 signaling pathway in rheumatoid arthritisQi Wu, Yixuan Qin, Yanan Chen, et al.Drug Design, Development and Therapy|September 3, 2024
A Randomized, Double-Blind, Parallel-Group Phase I Study Comparing the Pharmacokinetics, Safety, and Immunogenicity of CMAB015, a Candidate Secukinumab Biosimilar, with Its Reference Product Cosentyx® in Healthy Chinese Male SubjectsFeng Yao, Chenguang Wang, Jie Ding, et al.Expert Opinion on Investigational Drugs|May 24, 2025
Safety, pharmacokinetics, and efficacy of HY-072808 ointment, a novel PDE4 inhibitor, in adolescent and adult patients with mild-to-moderate ADFeng Yao, Mingchao He, Jing Wang, et al.International Immunopharmacology|April 18, 2026
TRPM7 inhibition alleviates acute gouty arthritis in mice by suppressing M1 polarization through the EDN1/EDNRB axisSu Wu, Yufan Zhang, Chen Jiang, et al.Theranostics|September 18, 2025
RIPK3 promotes ASIC1a-mediated fibroblast-like synoviocyte migration and invasion via malate shuttle-driven mitochondrial respiration in rheumatoid arthritisWeirong Hu, Ke Wang, Yalu Dong, et al.Diabetes, Obesity & Metabolism|December 15, 2023
Safety, pharmacokinetics and pharmacodynamics of HRS-7535, a novel oral small molecule glucagon-like peptide-1 receptor agonist, in healthy participants: A phase 1, randomized, double-blind, placebo-controlled, single- and multiple-ascending dose, and food effect trialJingying Wu, Renpeng Zhou, Qian Zhang, et al.International Immunopharmacology|April 6, 2024
TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKCα-HuR axis in rheumatoid arthritisYi Lin, Yong Chen, Weirong Hu, et al.European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences|July 11, 2026
AdipoRon Ameliorates Synovial Inflammatory Lesions and Joint Destruction in Experimental Arthritis by Downregulating KRT7Chen Jiang, Wei Zhang, Hanmei Ren, et al.Pageof 10