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Journal of Medicinal Chemistry|December 20, 2024
MoA Studies of the TEAD P-Site Binding Ligand MSC-4106 and Its Optimization to TEAD1-Selective Amide M3686Timo Heinrich, Daniel Schwarz, Carl Petersson, et al.Journal of Medicinal Chemistry|January 23, 2016
Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19Aurélie Mallinger, Kai Schiemann, Christian Rink, et al.Journal of Medicinal Chemistry|November 10, 2025
Phenotypic Hit Identification and Optimization of Novel Pan-TEAD and Subtype-Selective InhibitorsTimo Heinrich, Alessia Gambardella, Daniel Schwarz, et al.Nature Chemical Biology|October 27, 2015
A selective chemical probe for exploring the role of CDK8 and CDK19 in human diseaseTrevor Dale, Paul A Clarke, Christina Esdar, et al.Elife|December 10, 2016
Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinasesPaul A Clarke, Maria-Jesus Ortiz-Ruiz, Robert TePoele, et al.Pageof 4