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The Journal of Biological Chemistry|February 23, 2010
A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptakeYan G Ni, Jon H Condra, Laura Orsatti, et al.Cancer Research|June 4, 2024
Comprehensive Target Engagement by the EZH2 Inhibitor Tulmimetostat Allows for Targeting of ARID1A Mutant CancersPatricia J Keller, Elizabeth J Adams, Rentian Wu, et al.Journal of Medicinal Chemistry|October 15, 2016
Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell LymphomasRishi G Vaswani, Victor S Gehling, Les A Dakin, et al.Journal of Medicinal Chemistry|January 28, 2016
Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical TrialsBrian K Albrecht, Victor S Gehling, Michael C Hewitt, et al.Chemistry & Biology|December 3, 2014
EZH2 inhibitor efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27 monomethylationWilliam D Bradley, Shilpi Arora, Jennifer Busby, et al.Journal of Lipid Research|October 21, 2010
A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivoYan G Ni, Stefania Di Marco, Jon H Condra, et al.ACS Medicinal Chemistry Letters|July 26, 2017
GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2)Terry D Crawford, James E Audia, Steve Bellon, et al.Nature Chemical Biology|May 24, 2016
An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cellsMaia Vinogradova, Victor S Gehling, Amy Gustafson, et al.The Journal of Biological Chemistry|April 9, 2016
Regulatory T Cell Modulation by CBP/EP300 Bromodomain InhibitionSrimoyee Ghosh, Alexander Taylor, Melissa Chin, et al.ACS Medicinal Chemistry Letters|May 19, 2016
Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)Alexander M Taylor, Alexandre Côté, Michael C Hewitt, et al.Pageof 3