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Cell Adhesion & Migration|May 6, 2026
Dynamic modulation of intercellular adhesion mediated by matriptase-EPCAM/Trop-2 axes is critical for cell extrusion, division, and collective migrationYu-Ling A Kao, Qiaochu Wang, Dajun D Lu, et al.Human Cell|August 12, 2020
Mild acidity likely accelerates the physiological matriptase autoactivation process: a comparative study between spontaneous and acid-induced matriptase zymogen activationBailing Jia, Hamishi A Thompson, Robert B Barndt, et al.Plos One|February 13, 2020
The intracellular seven amino acid motif EEGEVFL is required for matriptase vesicle sorting and translocation to the basolateral plasma membraneChun-Che Tseng, Bailing Jia, Robert B Barndt, et al.Genes & Diseases|June 10, 2022
Differential subcellular distribution renders HAI-2 a less effective protease inhibitor than HAI-1 in the control of extracellular matriptase proteolytic activityYi-Lin Chiu, Yi-Ying Wu, Robert B Barndt, et al.Journal of Enzyme Inhibition and Medicinal Chemistry|February 20, 2019
Aberrant regulation favours matriptase proteolysis in neoplastic B-cells that co-express HAI-2Yi-Lin Chiu, Yi-Ying Wu, Robert B Barndt, et al.Human Cell|October 13, 2021
The difference in the intracellular Arg/Lys-rich and EHLVY motifs contributes to distinct subcellular distribution of HAI-1 versus HAI-2Nanxi Huang, Robert B Barndt, Dajun D Lu, et al.Human Molecular Genetics|June 5, 2021
Targeted HAI-2 deletion causes excessive proteolysis with prolonged active prostasin and depletion of HAI-1 monomer in intestinal but not epidermal epithelial cellsRobert B Barndt, Mon-Juan Lee, Nanxi Huang, et al.Plos One|December 10, 2016
Natural Endogenous Human Matriptase and Prostasin Undergo Zymogen Activation via Independent Mechanisms in an Uncoupled MannerHui Chen Su, Yan A Liang, Ying-Jung J Lai, et al.Pageof 1