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Proteins|March 19, 2014
Structure and specificity of an antibody targeting a proteolytically cleaved IgG hingeThomas J Malia, Alexey Teplyakov, Randall J Brezski, et al.Journal of the American College of Cardiology|July 11, 2002
Effects of abciximab on the acute pathology of blood vessels after arterial stenting in nonhuman primatesTullio Palmerini, Mark A Nedelman, Lesley E Scudder, et al.Breast Cancer Research : BCR|August 10, 2012
A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacyXuejun Fan, Randall J Brezski, Ming Fa, et al.Proceedings of the National Academy of Sciences of the United States of America|October 10, 2009
Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hingeRandall J Brezski, Omid Vafa, Diane Petrone, et al.Molecular Cancer Therapeutics|January 2, 2015
A novel therapeutic strategy to rescue the immune effector function of proteolytically inactivated cancer therapeutic antibodiesXuejun Fan, Randall J Brezski, Hui Deng, et al.Mabs|December 18, 2014
A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivoRandall J Brezski, Michelle Kinder, Katharine D Grugan, et al.Journal of Immunology (Baltimore, Md. : 1950)|August 21, 2008
Human anti-IgG1 hinge autoantibodies reconstitute the effector functions of proteolytically inactivated IgGsRandall J Brezski, Jennifer L Luongo, Diane Petrone, et al.Communications Biology|September 14, 2022
Impairment of IgG Fc functions promotes tumor progression and suppresses NK cell antitumor actionsXuejun Fan, Zihao Yuan, Yueshui Zhao, et al.The Journal of Biological Chemistry|August 30, 2013
Engineered protease-resistant antibodies with selectable cell-killing functionsMichelle Kinder, Allison R Greenplate, Katharine D Grugan, et al.Journal of Immunology (Baltimore, Md. : 1950)|October 30, 2012
Tumor-associated macrophages promote invasion while retaining Fc-dependent anti-tumor functionKatharine D Grugan, Francis L McCabe, Michelle Kinder, et al.Pageof 4