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Nature Communications|February 20, 2025
Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistributionNathalie Khoury, Michelle E Pizzo, Claire B Discenza, et al.Science Translational Medicine|May 29, 2020
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeysMihalis S Kariolis, Robert C Wells, Jennifer A Getz, et al.The Journal of Experimental Medicine|February 28, 2022
Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzymeAnnie Arguello, Cathal S Mahon, Meredith E K Calvert, et al.Cell Reports|July 24, 2025
Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large moleculesRobert C Wells, Padma Akkapeddi, Darren Chan, et al.Molecular Neurodegeneration|June 11, 2022
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microgliaDan Xia, Steve Lianoglou, Thomas Sandmann, et al.Science Translational Medicine|May 29, 2020
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in miceJulie C Ullman, Annie Arguello, Jennifer A Getz, et al.Science Translational Medicine|August 14, 2024
Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrierScarlett J Barker, Mai B Thayer, Chaeyoung Kim, et al.Nature Communications|August 19, 2023
CD98hc is a target for brain delivery of biotherapeuticsKylie S Chew, Robert C Wells, Arash Moshkforoush, et al.Science (New York, N.Y.)|August 7, 2025
Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIAMichelle E Pizzo, Edward D Plowey, Nathalie Khoury, et al.Nature Neuroscience|January 12, 2023
A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease modelsBettina van Lengerich, Lihong Zhan, Dan Xia, et al.Pageof 3