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Nucleic Acids Research|October 11, 2018
MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTPAnn-Sofie Jemth, Robert Gustafsson, Lars Bräutigam, et al.Cancer Research|February 11, 2016
Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 InhibitionLars Bräutigam, Linda Pudelko, Ann-Sofie Jemth, et al.Nature Communications|August 5, 2015
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2Megan Carter, Ann-Sofie Jemth, Anna Hagenkort, et al.Cancer Research|December 1, 2016
Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based InhibitorRobert Gustafsson, Ann-Sofie Jemth, Nina M S Gustafsson, et al.Nature|April 4, 2014
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP poolHelge Gad, Tobias Koolmeister, Ann-Sofie Jemth, et al.Nature Cancer|March 1, 2022
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stressNadilly Bonagas, Nina M S Gustafsson, Martin Henriksson, et al.Pageof 2