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The Journal of Biological Chemistry|February 1, 2021
Identification and characterization of second-generation EZH2 inhibitors with extended residence times and improved biological activityJacob I Stuckey, Nico R Cantone, Alexandre Côté, et al.
ACS Medicinal Chemistry Letters|June 20, 2020
Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence TimeAvinash Khanna, Alexandre Côté, Shilpi Arora, et al.
Nucleic Acids Research|June 13, 2023
SIRT1 regulates DNA damage signaling through the PP4 phosphatase complexGeorge Rasti, Maximilian Becker, Berta N Vazquez, et al.
Cell Chemical Biology|May 28, 2026
Covalent PPARγ inverse agonism by FX-909 reveals mechanistic insights into therapeutic targeting of PPARγ/RXRα-activated urothelial carcinomaJacob I Stuckey, Jennifer A Mertz, Jonathan E Wilson, et al.
Molecular Cell|October 12, 2021
NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brainSanxiong Liu, Kimberly A Aldinger, Chi Vicky Cheng, et al.
Cell Reports|November 2, 2017
Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2Aram S Modrek, Danielle Golub, Themasap Khan, et al.
Bioorganic & Medicinal Chemistry Letters|April 9, 2015
Development of methyl isoxazoleazepines as inhibitors of BETMichael C Hewitt, Yves Leblanc, Victor S Gehling, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|May 13, 2016
Regulation of GLI Underlies a Role for BET Bromodomains in Pancreatic Cancer Growth and the Tumor MicroenvironmentYinshi Huang, Sabikun Nahar, Akifumi Nakagawa, et al.
ACS Medicinal Chemistry Letters|March 18, 2016
Discovery of Benzotriazolo[4,3-d][1,4]diazepines as Orally Active Inhibitors of BET BromodomainsAlexander M Taylor, Rishi G Vaswani, Victor S Gehling, et al.
ACS Medicinal Chemistry Letters|June 6, 2014
Discovery, Design, and Optimization of Isoxazole Azepine BET InhibitorsVictor S Gehling, Michael C Hewitt, Rishi G Vaswani, et al.
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