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Bioorganic & Medicinal Chemistry Letters|October 22, 2011
Synthesis and evaluation of pyridone-phenoxypropyl-R-2-methylpyrrolidine analogues as histamine H3 receptor antagonistsNadine C Becknell, Jacquelyn A Lyons, Lisa D Aimone, et al.Bioorganic & Medicinal Chemistry Letters|February 12, 2014
Discovery of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one (R,S-4a): histamine H(3) receptor inverse agonist demonstrating potent cognitive enhancing and wake promoting activityRobert L Hudkins, Kurt A Josef, Nadine C Becknell, et al.Bioorganic & Medicinal Chemistry Letters|August 8, 2006
Novel C-3 N-urea, amide, and carbamate dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole analogs as potent TIE-2 and VEGF-R2 dual inhibitorsNadine C Becknell, Allison L Zulli, Thelma S Angeles, et al.Neuropharmacology|September 25, 2015
3-(1'-Cyclobutylspiro[4H-1,3-benzodioxine-2,4'-piperidine]-6-yl)-5,5-dimethyl-1,4-dihydropyridazin-6-one (CEP-32215), a new wake-promoting histamine H3 antagonist/inverse agonistRobert L Hudkins, John A Gruner, Rita Raddatz, et al.European Journal of Medicinal Chemistry|April 2, 2015
3,4-Diaza-bicyclo[4.1.0]hept-4-en-2-one phenoxypropylamine analogs of irdabisant (CEP-26401) as potent histamine-3 receptor inverse agonists with robust wake-promoting activityRobert L Hudkins, Nadine C Becknell, Jacquelyn A Lyons, et al.Bioorganic & Medicinal Chemistry Letters|September 28, 2011
Synthesis and evaluation of pyridazinone-phenethylamine derivatives as selective and orally bioavailable histamine H3 receptor antagonists with robust wake-promoting activityReddeppa Reddy Dandu, John A Gruner, Joanne R Mathiasen, et al.Bioorganic & Medicinal Chemistry Letters|March 18, 2008
TIE-2/VEGF-R2 SAR and in vitro activity of C3-acyl dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole analogsTed L Underiner, Bruce Ruggeri, Lisa Aimone, et al.Bioorganic & Medicinal Chemistry Letters|December 7, 2011
4,5-dihydropyridazin-3-one derivatives as histamine H₃ receptor inverse agonistsRobert L Hudkins, Lisa D Aimone, Reddeppa Reddy Dandu, et al.Bioorganic & Medicinal Chemistry Letters|February 1, 2012
4-phenoxypiperidine pyridazin-3-one histamine H(3) receptor inverse agonists demonstrating potent and robust wake promoting activityRobert L Hudkins, Allison L Zulli, Reddeppa reddy Dandu, et al.Bioorganic & Medicinal Chemistry Letters|May 1, 2010
8-THP-DHI analogs as potent Type I dual TIE-2/VEGF-R2 receptor tyrosine kinase inhibitorsRobert L Hudkins, Allison L Zulli, Ted L Underiner, et al.Pageof 5