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Robert M Garbaccio

Showing results (11-20 of 36) with videos related to

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Science (New York, N.Y.)|January 19, 2019
The importance of synthetic chemistry in the pharmaceutical industryKevin R Campos, Paul J Coleman, Juan C Alvarez, et al.
Bioconjugate Chemistry|July 30, 2016
Novel Phosphate Modified Cathepsin B Linkers: Improving Aqueous Solubility and Enhancing Payload Scope of ADCsJeffrey C Kern, Deborah Dooney, Rena Zhang, et al.
Bioconjugate Chemistry|March 19, 2013
Endosomolytic bioreducible poly(amido amine disulfide) polymer conjugates for the in vivo systemic delivery of siRNA therapeuticsRubina Giare Parmar, Marina Busuek, Eileen S Walsh, et al.
Bioorganic & Medicinal Chemistry Letters|May 13, 2014
Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolaseAntonella Converso, Timothy Hartingh, Mark E Fraley, et al.
The Journal of Organic Chemistry|October 30, 2019
Multiple Synthetic Routes to the Mini-Protein Omomyc and Coiled-Coil Domain TruncationsZachary Z Brown, Claudio Mapelli, Iman Farasat, et al.
ACS Medicinal Chemistry Letters|June 6, 2014
Discovery of Oxazolobenzimidazoles as Positive Allosteric Modulators for the mGluR2 ReceptorRobert M Garbaccio, Edward J Brnardic, Mark E Fraley, et al.
Bioorganic & Medicinal Chemistry Letters|January 27, 2016
Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosisMark E Layton, Alexander J Reif, Timothy J Hartingh, et al.
Bioorganic & Medicinal Chemistry Letters|March 31, 2007
Kinesin spindle protein (KSP) inhibitors. Part V: discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by beta-fluorination to overcome cellular efflux by P-glycoproteinChristopher D Cox, Michael J Breslin, David B Whitman, et al.
Bioorganic & Medicinal Chemistry Letters|April 23, 2010
3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead effortsEdward J Brnardic, Mark E Fraley, Robert M Garbaccio, et al.
ACS Medicinal Chemistry Letters|March 18, 2016
Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDIJoseph E Pero, Michael A Rossi, Michael J Kelly, et al.
Pageof 4

Showing results (11-20 of 36) with videos related to

Sort By:
Pageof 4
Science (New York, N.Y.)|January 19, 2019
The importance of synthetic chemistry in the pharmaceutical industryKevin R Campos, Paul J Coleman, Juan C Alvarez, et al.
Bioconjugate Chemistry|July 30, 2016
Novel Phosphate Modified Cathepsin B Linkers: Improving Aqueous Solubility and Enhancing Payload Scope of ADCsJeffrey C Kern, Deborah Dooney, Rena Zhang, et al.
Bioconjugate Chemistry|March 19, 2013
Endosomolytic bioreducible poly(amido amine disulfide) polymer conjugates for the in vivo systemic delivery of siRNA therapeuticsRubina Giare Parmar, Marina Busuek, Eileen S Walsh, et al.
Bioorganic & Medicinal Chemistry Letters|May 13, 2014
Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolaseAntonella Converso, Timothy Hartingh, Mark E Fraley, et al.
The Journal of Organic Chemistry|October 30, 2019
Multiple Synthetic Routes to the Mini-Protein Omomyc and Coiled-Coil Domain TruncationsZachary Z Brown, Claudio Mapelli, Iman Farasat, et al.
ACS Medicinal Chemistry Letters|June 6, 2014
Discovery of Oxazolobenzimidazoles as Positive Allosteric Modulators for the mGluR2 ReceptorRobert M Garbaccio, Edward J Brnardic, Mark E Fraley, et al.
Bioorganic & Medicinal Chemistry Letters|January 27, 2016
Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosisMark E Layton, Alexander J Reif, Timothy J Hartingh, et al.
Bioorganic & Medicinal Chemistry Letters|March 31, 2007
Kinesin spindle protein (KSP) inhibitors. Part V: discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by beta-fluorination to overcome cellular efflux by P-glycoproteinChristopher D Cox, Michael J Breslin, David B Whitman, et al.
Bioorganic & Medicinal Chemistry Letters|April 23, 2010
3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead effortsEdward J Brnardic, Mark E Fraley, Robert M Garbaccio, et al.
ACS Medicinal Chemistry Letters|March 18, 2016
Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDIJoseph E Pero, Michael A Rossi, Michael J Kelly, et al.
Pageof 4