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The Journal of Biological Chemistry|November 17, 2012
Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studiesLimor Avrahami, Dorit Farfara, Maya Shaham-Kol, et al.
The Journal of Biological Chemistry|October 11, 2008
X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brainYuhki Saito, Yoshitake Sano, Robert Vassar, et al.
Autophagy|October 30, 2016
Identification of natural products with neuronal and metabolic benefits through autophagy inductionYuying Fan, Nan Wang, Altea Rocchi, et al.
The Journal of Biological Chemistry|September 19, 2012
β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defectsBrian Hitt, Sean M Riordan, Lokesh Kukreja, et al.
The Journal of Biological Chemistry|January 22, 2026
Alzheimer's disease-linked ACE variants increase ACE1 catalytic activity and production of angiotensin IIMiranda A Salvo, Leah K Cuddy, Dmitry Prokopenko, et al.
The Journal of Biological Chemistry|February 19, 2005
Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanismSarah L Cole, Aneta Grudzien, Ingrid O Manhart, et al.
Acta Neuropathologica|March 20, 2016
Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's diseaseKatherine R Sadleir, Patty C Kandalepas, Virginie Buggia-Prévot, et al.
The Journal of Experimental Medicine|January 17, 2019
3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in miceDivna Lazic, Abhay P Sagare, Angeliki M Nikolakopoulou, et al.
Acta Neuropathologica|July 4, 2013
The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaquesPatty C Kandalepas, Katherine R Sadleir, William A Eimer, et al.
Science Bulletin|October 23, 2024
Now and future: Strategies for diagnosis, prevention and therapies for Alzheimer's diseaseJiong Shi, Jacques Touchon, Lefkos T Middleton, et al.
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