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ACS Chemical Biology|July 2, 2025
Mediator Kinase Inhibitor Selectivity and Activity in Colorectal CancerMaria J Ortiz-Ruiz, Olajumoke Popoola, Konstantinos Mitsopoulos, et al.Medchemcomm|October 18, 2016
Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9Carl S Rye, Nicola E A Chessum, Scott Lamont, et al.Journal of Medicinal Chemistry|April 5, 2023
HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other MalignanciesA Elisa Pasqua, Swee Y Sharp, Nicola E A Chessum, et al.Journal of Medicinal Chemistry|December 23, 2016
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic ScreenMatthew D Cheeseman, Nicola E A Chessum, Carl S Rye, et al.Hepatology (Baltimore, Md.)|December 28, 2019
Modulation of Biliary Cancer Chemo-Resistance Through MicroRNA-Mediated Rewiring of the Expansion of CD133+ CellsPietro Carotenuto, Somaieh Hedayat, Matteo Fassan, et al.Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|January 9, 2025
NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer GrowthJonathan Welti, Denisa Bogdan, Ines Figueiredo, et al.Pageof 2