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European Journal of Organic Chemistry|November 5, 2019
Protein-Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental ProtocolAlwin M Hartman, Robin M Gierse, Anna K H HirschJournal of Medicinal Chemistry|June 7, 2018
Druggability Assessment of Targets Used in Kinetic Target-Guided SynthesisM Yagiz Unver, Robin M Gierse, Harry Ritchie, et al.Journal of Structural Biology|August 10, 2025
1-Deoxy-D-xylulose 5-phosphate synthase: structural perspectives on an essential enzyme in isoprenoid biosynthesisVictor O Gawriljuk, Rick Oerlemans, Eswar R Reddem, et al.Biochemical and Biophysical Research Communications|January 9, 2021
Identification of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) mutant with improved crystallographic propertiesRobin M Gierse, Eswar R Reddem, Alaa Alhayek, et al.Chemmedchem|September 5, 2018
Design and Synthesis of Bioisosteres of Acylhydrazones as Stable Inhibitors of the Aspartic Protease EndothiapepsinVarsha R Jumde, Milon Mondal, Robin M Gierse, et al.Chemmedchem|March 10, 2023
Not Every Hit-Identification Technique Works on 1-Deoxy-d-Xylulose 5-Phosphate Synthase (DXPS): Making the Most of a Virtual Screening CampaignSandra Johannsen, Robin M Gierse, Aleksandra Olshanova, et al.Scientific Reports|May 4, 2022
First crystal structures of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilizationRobin M Gierse, Rick Oerlemans, Eswar R Reddem, et al.Chemical Science|June 25, 2021
Hit-optimization using target-directed dynamic combinatorial chemistry: development of inhibitors of the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthaseRavindra P Jumde, Melissa Guardigni, Robin M Gierse, et al.Chemical Science|November 2, 2022
Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screeningDi Zhu, Sandra Johannsen, Tiziana Masini, et al.ACS Infectious Diseases|February 17, 2024
High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of <i>Plasmodium falciparum</i>Sandra Johannsen, Robin M Gierse, Arne Krüger, et al.Pageof 1