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CPT: Pharmacometrics & Systems Pharmacology|June 13, 2024
Quantification of the effect of GLP-1R agonists on body weight using in vitro efficacy information: An extension of the Hall body composition modelRolien Bosch, Eric J G Sijbrands, Nelleke Snelder
CPT: Pharmacometrics & Systems Pharmacology|July 16, 2025
From In Vitro Efficacy to Long-Term HbA1c Response for GLP-1R/GlucagonR Agonism Using the 4GI-HbA1c Systems ModelRolien Bosch, Marcella Petrone, Rosalin Arends, et al.
CPT: Pharmacometrics & Systems Pharmacology|May 8, 2024
Navigating the landscape of parameter identifiability methods: A workflow recommendation for model developmentMartijn van Noort, Martijn Ruppert, Joost DeJongh, et al.
CPT: Pharmacometrics & Systems Pharmacology|December 10, 2021
A novel integrated QSP model of in vivo human glucose regulation to support the development of a glucagon/GLP-1 dual agonistRolien Bosch, Marcella Petrone, Rosalin Arends, et al.
British Journal of Pharmacology|February 25, 2024
Characterisation of cotadutide's dual GLP-1/glucagon receptor agonistic effects on glycaemic control using an in vivo human glucose regulation quantitative systems pharmacology modelRolien Bosch, Marcella Petrone, Rosalin Arends, et al.
Biophysical Journal|August 15, 2006
Enantioselective substrate binding in a monooxygenase protein model by molecular dynamics and dockingK Anton Feenstra, Karin Hofstetter, Rolien Bosch, et al.
Clinical and Translational Science|November 24, 2019
Making Better Dose Decisions: Using Exposure-Response Modeling to Integrate Efficacy Outcome of Two Phase IIb Clinical Trials of Ubrogepant for Migraine TreatmentChi-Chung Li, Tiffini Voss, Ken Kowalski, et al.
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences|January 10, 2016
A PK-PD model-based assessment of sugammadex effects on coagulation parametersRolien Bosch, Marie-José van Lierop, Pieter-Jan de Kam, et al.
The Journal of Biological Chemistry|April 27, 2012
X-ray structures of progesterone receptor ligand binding domain in its agonist state reveal differing mechanisms for mixed profiles of 11β-substituted steroidsScott J Lusher, Hans C A Raaijmakers, Diep Vu-Pham, et al.
The Journal of Biological Chemistry|August 19, 2011
Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulatorsScott J Lusher, Hans C A Raaijmakers, Diep Vu-Pham, et al.
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