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Journal of Medicinal Chemistry|June 12, 2026
(S,S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((1-(pyridin-4-yl)ethyl)amino)propan-2-yl)-1H-indole-2-carboxamide, a New Dishevelled 1 and P-Glycoprotein Dual Inhibitor as a Anticancer AgentMichela Puxeddu, Zeyu Cui, Claudia Colla, et al.Journal of Medicinal Chemistry|July 16, 2009
New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studiesGiuseppe La Regina, Taradas Sarkar, Ruoli Bai, et al.European Journal of Medicinal Chemistry|May 30, 2021
Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemiaMichela Puxeddu, Hongliang Shen, Ruoli Bai, et al.Chemmedchem|February 25, 2026
4-(5-Chloro-3-(3,4,5-trimethoxybenzoyl)-1H-indol-1-yl)benzenesulfonamide: A Novel Polypharmacology Agent to Target Carbonic Anhydrase IX and XII With Improved Selectivity, Wnt/β-Catenin Signaling Pathway, and P-GlycoproteinMichela Puxeddu, Rosa Bordone, Claudia Colla, et al.Journal of Medicinal Chemistry|November 7, 2024
Development of N-(4-(1H-Imidazol-1-yl)phenyl)-4-chlorobenzenesulfonamide, a Novel Potent Inhibitor of β-Catenin with Enhanced Antitumor Activity and Metabolic StabilityMichela Puxeddu, Lele Ling, Silvia Ripa, et al.ACS Medicinal Chemistry Letters|May 20, 2017
3-Aroyl-1,4-diarylpyrroles Inhibit Chronic Myeloid Leukemia Cell Growth through an Interaction with TubulinGiuseppe La Regina, Ruoli Bai, Antonio Coluccia, et al.Journal of Medicinal Chemistry|November 3, 2011
Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stabilityGiuseppe La Regina, Ruoli Bai, Willeke Rensen, et al.ACS Infectious Diseases|August 3, 2024
4-(3-Phenylsulfonylindol-2-yl)-1-(pyridin-2-yl)piperazinyl-methanones as Potent Inhibitors of both SARS-CoV-2 and HCoV-OC43 VirusesMichela Puxeddu, Manuela Donalisio, Joachim Jakob Bugert, et al.Journal of Medicinal Chemistry|July 16, 2014
New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancerGiuseppe La Regina, Ruoli Bai, Antonio Coluccia, et al.Journal of Medicinal Chemistry|October 30, 2023
4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer CellsDomiziana Masci, Michela Puxeddu, Laura Di Magno, et al.Pageof 16