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Biorxiv : the Preprint Server for Biology|November 24, 2025
Cryo-EM reveals how ASX-173 inhibits human asparagine synthetase to activate the integrated stress responseKirk A Staschke, Nicholas T Walda, Lucciano A Pearce, et al.
The Journal of Nutrition|September 24, 2010
The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginasePiyawan Bunpo, Judy K Cundiff, Rachel B Reinert, et al.
Eukaryotic Cell|November 10, 2005
Stress-activated protein kinase pathway functions to support protein synthesis and translational adaptation in response to environmental stress in fission yeastIsabelle Dunand-Sauthier, Carol A Walker, Jana Narasimhan, et al.
Diabetes|October 12, 2007
The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell deathKari T Chambers, Julie A Unverferth, Sarah M Weber, et al.
The Journal of Biological Chemistry|April 25, 2013
Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein responseJustin T Babcock, Hoa B Nguyen, Yujun He, et al.
American Journal of Physiology. Gastrointestinal and Liver Physiology|March 13, 2016
General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in miceLindsey Phillipson-Weiner, Emily T Mirek, Yongping Wang, et al.
The Journal of Biological Chemistry|April 24, 2026
An inhibitor of GCN2 and the integrated stress response directly targets ZAK protein kinase to limit cytotoxicityJagannath Misra, Dan F Spandau, Jonah Z Vilseck, et al.
Molecular and Cellular Biology|September 21, 2002
Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stressesKe Zhan, Krishna M Vattem, Bettina N Bauer, et al.
Cell Death & Disease|March 16, 2018
Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4Joy Ogbechi, Belinda S Hall, Thomas Sbarrato, et al.
Biochemical and Biophysical Research Communications|December 17, 2013
Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2Tavane D Cambiaghi, Catia M Pereira, Renuka Shanmugam, et al.
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