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The Journal of Pharmacology and Experimental Therapeutics|February 19, 2025
First-in-class mitogen-activated protein kinase (MAPK) p38α: MAPK-activated protein kinase 2 dual signal modulator with anti-inflammatory and endothelial-stabilizing propertiesMohan E Tulapurkar, Kari Ann Shirey, Katerina Lugkey, et al.The Journal of Pharmacology and Experimental Therapeutics|September 16, 2024
First-in-Class Mitogen-Activated Protein Kinase p38α: MAPK-Activated Protein Kinase-2 (MK2) Dual Signal Modulator with Anti-inflammatory and Endothelial-stabilizing PropertiesMohan E Tulapurkar, Kari Ann Shirey, Katerina N Lugkey, et al.Blood|April 18, 2022
The ERK2-DBP domain opposes pathogenesis of a mouse JAK2V617F-driven myeloproliferative neoplasmYong Zhang, Billy Truong, Shawn P Fahl, et al.Molecular Cancer|May 18, 2013
The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with BakXiaobo Cao, Jeremy L Yap, M Karen Newell-Rogers, et al.Organic & Biomolecular Chemistry|April 30, 2013
Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signalingKwan-Young Jung, Ramin Samadani, Jay Chauhan, et al.Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|December 23, 2020
VLA4-Targeted Nanoparticles Hijack Cell Adhesion-Mediated Drug Resistance to Target Refractory Myeloma Cells and Prolong SurvivalFrancesca Fontana, Michael J Scott, John S Allen, et al.European Journal of Medicinal Chemistry|March 18, 2016
Structure-based design of N-substituted 1-hydroxy-4-sulfamoyl-2-naphthoates as selective inhibitors of the Mcl-1 oncoproteinMaryanna E Lanning, Wenbo Yu, Jeremy L Yap, et al.Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology|December 6, 2006
Phase III trial of gabapentin alone or in conjunction with an antidepressant in the management of hot flashes in women who have inadequate control with an antidepressant alone: NCCTG N03C5Charles L Loprinzi, John W Kugler, Debra L Barton, et al.Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|June 23, 2019
Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic TumorsAslamuzzaman Kazi, Shengyan Xiang, Hua Yang, et al.Journal of Medicinal Chemistry|September 9, 2010
Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agentsSteven Fletcher, Erin Pusateri Keaney, Christopher G Cummings, et al.Pageof 11