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Biochemistry|June 14, 2006
Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitorsKenton L Longenecker, Kent D Stewart, David J Madar, et al.Developmental Cell|July 11, 2003
Suppression of beta cell energy metabolism and insulin release by PGC-1alphaJ Cliff Yoon, Gang Xu, Jude T Deeney, et al.Journal of Medicinal Chemistry|July 21, 2006
Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitorsHongyu Zhao, Michael D Serby, Zhili Xin, et al.Journal of Rnai and Gene Silencing : an International Journal of RNA and Gene Targeting Research|September 23, 2009
Delivery of RNAi reagents in murine models of obesity and diabetesDenise M Wilcox, Ruojing Yang, Sherry J Morgan, et al.JCI Insight|January 12, 2018
A glucose-responsive insulin therapy protects animals against hypoglycemiaRuojing Yang, Margaret Wu, Songnian Lin, et al.Proceedings of the National Academy of Sciences of the United States of America|August 10, 2002
PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic miceBradley A Zinker, Cristina M Rondinone, James M Trevillyan, et al.Bioorganic & Medicinal Chemistry Letters|February 6, 2007
Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hitBradley J Backes, Kenton Longenecker, Gregory L Hamilton, et al.ACS Medicinal Chemistry Letters|June 24, 2015
Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4Jongwon Lim, Michael D Altman, James Baker, et al.Journal of Medicinal Chemistry|October 27, 2006
Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetesZhonghua Pei, Xiaofeng Li, Thomas W von Geldern, et al.Journal of Medicinal Chemistry|May 29, 2007
Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitorsGang Liu, John K Lynch, Jennifer Freeman, et al.Pageof 6