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The Journal of Biological Chemistry|July 20, 2007
Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigsAndrew D Nguyen, Jeffrey G McDonald, Richard K Bruick, et al.Elife|March 6, 2015
The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductaseMarc M Schumacher, Rania Elsabrouty, Joachim Seemann, et al.Proceedings of the National Academy of Sciences of the United States of America|February 6, 2024
Direct binding to sterols accelerates endoplasmic reticulum-associated degradation of HMG CoA reductaseRebecca A Faulkner, Yangyan Yang, Jet Tsien, et al.Elife|November 29, 2021
Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1Rania Elsabrouty, Youngah Jo, Seonghwan Hwang, et al.Journal of Lipid Research|April 29, 2016
Geranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between membranes of the ER and GolgiMarc M Schumacher, Dong-Jae Jun, Youngah Jo, et al.Molecular Cell|January 22, 2003
Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domainNavdar Sever, Tong Yang, Michael S Brown, et al.The Journal of Biological Chemistry|May 27, 2014
Sequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, endoplasmic reticulum (ER)-associated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductaseLindsey L Morris, Isamu Z Hartman, Dong-Jae Jun, et al.The Journal of Biological Chemistry|April 19, 2017
Hypoxia-inducible factor 1α activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liverSeonghwan Hwang, Andrew D Nguyen, Youngah Jo, et al.The Journal of Biological Chemistry|July 13, 2004
Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductaseNavdar Sever, Peter C W Lee, Bao-Liang Song, et al.The Journal of Biological Chemistry|October 18, 2003
Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniolNavdar Sever, Bao-Liang Song, Daisuke Yabe, et al.Pageof 5