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Biopharmaceutics & Drug Disposition|June 16, 2007
Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligandsAndrew Pike, Susan M Cook, Alan P Watt, et al.Neuropharmacology|January 25, 2006
The in vivo properties of pagoclone in rat are most likely mediated by 5'-hydroxy pagocloneJohn R Atack, Andy Pike, George Marshall, et al.The Journal of Neuroscience : the Official Journal of the Society for Neuroscience|July 5, 2002
Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptorNeil Collinson, Frederick M Kuenzi, Wolfgang Jarolimek, et al.Bioorganic & Medicinal Chemistry Letters|June 5, 2004
2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptorAndrew Mitchinson, John R Atack, Peter Blurton, et al.Journal of Medicinal Chemistry|April 19, 2002
3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channelsIan Collins, Christopher Moyes, William B Davey, et al.The Journal of Pharmacology and Experimental Therapeutics|September 27, 2005
TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primatesJohn R Atack, Keith A Wafford, Spencer J Tye, et al.Journal of Medicinal Chemistry|March 19, 2004
3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1Robert W Carling, Kevin W Moore, Leslie J Street, et al.Journal of Medicinal Chemistry|March 4, 2005
Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABA A receptor agonists at the alpha3 subunitMichael G N Russell, Robert W Carling, John R Atack, et al.Science Translational Medicine|April 22, 2016
Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgiaLishuang Cao, Aoibhinn McDonnell, Anja Nitzsche, et al.Journal of Medicinal Chemistry|November 11, 2005
7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal modelsRobert W Carling, Andrew Madin, Alec Guiblin, et al.Pageof 3