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Nature Communications|July 13, 2023
Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradationRyan P Wurz, Huan Rui, Ken Dellamaggiore, et al.Bioorganic & Medicinal Chemistry Letters|December 27, 2011
Identification of triazolopyridazinones as potent p38α inhibitorsBrad Herberich, Claire Jackson, Ryan P Wurz, et al.Bioorganic & Medicinal Chemistry Letters|February 9, 2010
Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinaseRyan P Wurz, Liping H Pettus, Bradley Henkle, et al.Bioorganic & Medicinal Chemistry Letters|July 4, 2009
Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinaseRyan P Wurz, Liping H Pettus, Shimin Xu, et al.Journal of Medicinal Chemistry|August 18, 2010
Discovery of pyridazinopyridinones as potent and selective p38 mitogen-activated protein kinase inhibitorsBin Wu, Hui-Ling Wang, Liping Pettus, et al.Organic Letters|August 8, 2024
Structural Elucidation and Absolute Stereochemistry for Pharma Compounds Using MicroEDLygia Silva de Moraes, Jessica E Burch, David A Delgadillo, et al.Bioorganic & Medicinal Chemistry Letters|January 25, 2015
Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitorsBin Wu, Hui-Ling Wang, Victor J Cee, et al.Journal of Medicinal Chemistry|March 12, 2010
Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinaseLiping H Pettus, Ryan P Wurz, Shimin Xu, et al.Bioorganic & Medicinal Chemistry Letters|July 27, 2012
Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffoldRyan P Wurz, Longbin Liu, Kevin Yang, et al.Nature Communications|August 21, 2025
LYMTACs:chimeric small molecules repurpose lysosomal membrane proteins for target protein relocalization and degradationDhanusha A Nalawansha, Georgios Mazis, Gitte Husemoen, et al.Pageof 4