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Chemical Science|January 26, 2024
The Minimum Protein Staple? - Towards 'bio'-Baldwin's rules via inter-phosphosite linking in the MEK1 activation loopSébastien R G Galan, Ritu Raj, Dimitrios Mamalis, et al.Journal of the American Chemical Society|January 8, 2014
Synthetic phosphorylation of p38α recapitulates protein kinase activityK Phin Chooi, Sébastien R G Galan, Ritu Raj, et al.Bioorganic Chemistry|November 18, 2019
Characterisation of utrophin modulator SMT C1100 as a non-competitive inhibitor of firefly luciferaseIsabel V L Wilkinson, Jessica K Reynolds, Sébastien R G Galan, et al.ACS Chemical Biology|September 15, 2018
Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX InhibitorsJakub Stefaniak, Andrew M Lewis, Daniel Conole, et al.Nature Chemical Biology|September 19, 2018
Post-translational site-selective protein backbone α-deuterationSébastien R G Galan, James R Wickens, Jitka Dadova, et al.ACS Medicinal Chemistry Letters|February 17, 2022
Pilot Study to Quantify Palladium Impurities in Lead-like Compounds Following Commonly Used Purification TechniquesMaria Chatzopoulou, Katrina S Madden, Liam J Bromhead, et al.ACS Medicinal Chemistry Letters|April 21, 2015
Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related PainMark D Andrews, Kerry Af Forselles, Kevin Beaumont, et al.RSC Medicinal Chemistry|September 2, 2024
Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemiaThomas J Cogswell, Laia Josa-Culleré, David Zimmer, et al.Cell|May 1, 2021
LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteomeKuan-Yu Lai, Sébastien R G Galan, Yibo Zeng, et al.European Journal of Medicinal Chemistry|June 21, 2023
Phenotypic screening identifies a trisubstituted imidazo[1,2-a]pyridine series that induces differentiation in multiple AML cell linesLaia Josa-Culleré, Sébastien R G Galan, Thomas J Cogswell, et al.Pageof 2