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Bioorganic & Medicinal Chemistry Letters|January 18, 2014
Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®Timothy A Blizzard, Helen Chen, Seongkon Kim, et al.Plos One|July 13, 2017
Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyraseScott S Walker, Marc Labroli, Ronald E Painter, et al.Chemistry & Biology|October 13, 2015
Elucidation of DnaE as the Antibacterial Target of the Natural Product, NargenicinRonald E Painter, Gregory C Adam, Marta Arocho, et al.Antimicrobial Agents and Chemotherapy|April 18, 2022
Imipenem/Relebactam Resistance in Clinical Isolates of Extensively Drug Resistant Pseudomonas aeruginosa: Inhibitor-Resistant β-Lactamases and Their Increasing ImportanceAndrea M Hujer, Christopher R Bethel, Magdalena A Taracila, et al.Chemistry & Biology|August 27, 2011
Discovery of kibdelomycin, a potent new class of bacterial type II topoisomerase inhibitor by chemical-genetic profiling in Staphylococcus aureusJohn W Phillips, Michael A Goetz, Scott K Smith, et al.Nature Communications|April 10, 2025
Antibacterial macrocyclic peptides reveal a distinct mode of BamA inhibitionMorgan E Walker, Wei Zhu, Janine H Peterson, et al.Proceedings of the National Academy of Sciences of the United States of America|October 9, 2019
A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrierElizabeth M Hart, Angela M Mitchell, Anna Konovalova, et al.Bioorganic & Medicinal Chemistry Letters|October 13, 2024
Discovery of sulfone containing metallo-β-lactamase inhibitors with reduced bacterial cell efflux and histamine release issuesFrank Bennett, Yuhua Huang, Shuzhi Dong, et al.Nature|September 30, 2015
Selective small-molecule inhibition of an RNA structural elementJohn A Howe, Hao Wang, Thierry O Fischmann, et al.Nature Medicine|January 13, 2026
Discovery and development of a new oxazolidinone with reduced toxicity for the treatment of tuberculosisBrendan M Crowley, Helena I Boshoff, Aidan Boving, et al.Pageof 12