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Human Molecular Genetics|March 17, 2018
Modulation of β-glucocerebrosidase increases α-synuclein secretion and exosome release in mouse models of Parkinson's diseaseVassilis E Papadopoulos, Georgia Nikolopoulou, Ivi Antoniadou, et al.
Neurobiology of Disease|January 7, 2022
A double-hit in vivo model of GBA viral microRNA-mediated downregulation and human alpha-synuclein overexpression demonstrates nigrostriatal degenerationAlexia Polissidis, Effrosyni Koronaiou, Georgia Nikolopoulou, et al.
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism|August 30, 2008
Neuregulin-1 signaling in brain endothelial cellsJosephine Lok, S Pablo Sardi, Shuzhen Guo, et al.
Molecular Genetics and Metabolism|October 17, 2024
Pompe disease: Unmet needs and emerging therapiesKelly A George, Allyson L Anding, Arjan van der Flier, et al.
Scientific Reports|October 23, 2021
Preclinical pharmacology of glucosylceramide synthase inhibitor venglustat in a GBA-related synucleinopathy modelCatherine Viel, Jennifer Clarke, Can Kayatekin, et al.
Alzheimer'S Research & Therapy|February 2, 2022
Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer's diseaseJames C Dodge, Thomas J Tamsett, Christopher M Treleaven, et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience|October 14, 2020
Neutral Lipid Cacostasis Contributes to Disease Pathogenesis in Amyotrophic Lateral SclerosisJames C Dodge, Elizabeth H Jensen, Jinlong Yu, et al.
Endocrinology|April 14, 2011
SynCAM1, a synaptic adhesion molecule, is expressed in astrocytes and contributes to erbB4 receptor-mediated control of female sexual developmentUrsula S Sandau, Alison E Mungenast, Zefora Alderman, et al.
The Journal of Clinical Investigation|March 18, 2010
CNS-targeted gene therapy improves survival and motor function in a mouse model of spinal muscular atrophyMarco A Passini, Jie Bu, Eric M Roskelley, et al.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie|March 15, 2022
A novel brain-penetrant oral UGT8 inhibitor decreases in vivo galactosphingolipid biosynthesis in murine Krabbe diseaseEva Zaccariotto, María Begoña Cachón-González, Bing Wang, et al.
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