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Journal of Medicinal Chemistry|May 9, 2013
Discovery of N-{4-[(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybenzamide analogues as selective kappa opioid receptor antagonistsChad M Kormos, Chunyang Jin, Juan Pablo Cueva, et al.Journal of Medicinal Chemistry|July 24, 2018
Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)- N-[1 R)-1-(Cyclohexylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (CDTic)Chad M Kormos, Pauline W Ondachi, Scott P Runyon, et al.Journal of Medicinal Chemistry|August 18, 2018
Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3 R)-7-Hydroxy- N-[(1 S)-2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic)Pauline W Ondachi, Chad M Kormos, Scott P Runyon, et al.Journal of Medicinal Chemistry|June 1, 2010
Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessationRonald J Lukas, Ana Z Muresan, M Imad Damaj, et al.Journal of Medicinal Chemistry|June 27, 2003
Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonistJames B Thomas, Robert N Atkinson, N Ariane Vinson, et al.ACS Chemical Neuroscience|September 15, 2015
Novel Synthesis and Pharmacological Characterization of NOP Receptor Agonist 8-[(1S,3aS)-2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198)Steven D Chang, Lawrence E Brieaddy, Joseph D Harvey, et al.Journal of Medicinal Chemistry|July 26, 2002
Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphansJames B Thomas, Robert N Atkinson, Nivedita Namdev, et al.Nature|March 23, 2012
Structure of the human κ-opioid receptor in complex with JDTicHuixian Wu, Daniel Wacker, Mauro Mileni, et al.Pageof 5