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Journal of Biomolecular Screening|June 26, 2013
A label-free LC/MS/MS-based enzymatic activity assay for the detection of genuine caspase inhibitors and SAR developmentMichel C Maillard, Celia Dominguez, Mark J Gemkow, et al.Journal of Biomolecular Screening|April 17, 2010
A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitorsSabine Schaertl, Michael Prime, John Wityak, et al.Current Drug Discovery Technologies|February 14, 2006
Experiences in implementing uHTS--cutting edge technology meets the real worldPhilip Gribbon, Sabine Schaertl, Malcolm Wickenden, et al.Metabolites|August 25, 2022
A Novel and Cross-Species Active Mammalian INDY (NaCT) Inhibitor Ameliorates Hepatic Steatosis in Mice with Diet-Induced ObesityGrit Zahn, Diana M Willmes, Nermeen N El-Agroudy, et al.ACS Medicinal Chemistry Letters|June 6, 2014
SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington's DiseaseJohn Wityak, Michael E Prime, Frederick A Brookfield, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Irreversible 4-Aminopiperidine Transglutaminase 2 Inhibitors for Huntington's DiseaseMichael E Prime, Frederick A Brookfield, Stephen M Courtney, et al.Bioorganic & Medicinal Chemistry|September 10, 2011
Exploiting differences in caspase-2 and -3 S₂ subsites for selectivity: structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitorsMichel C Maillard, Frederick A Brookfield, Stephen M Courtney, et al.Science Translational Medicine|February 2, 2022
Development of a ligand for in vivo imaging of mutant huntingtin in Huntington's diseaseDaniele Bertoglio, Jonathan Bard, Manuela Hessmann, et al.Bioorganic & Medicinal Chemistry Letters|July 4, 2025
Orthosteric inhibition of MutSβ ATPase function: First disclosure of MSH3-bound small molecule inhibitorsGareth N Brace, Karsten Tillack, Peter D Johnson, et al.Scientific Reports|September 10, 2021
Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidatesFrank Herrmann, Manuela Hessmann, Sabine Schaertl, et al.Pageof 2