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The Journal of Biological Chemistry|September 29, 2005
Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forksA Kathleen McClendon, A Chapin Rodriguez, Neil Osheroff
Nature Structural & Molecular Biology|October 2, 2012
Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activityBryan H Schmidt, Neil Osheroff, James M Berger
The Journal of Biological Chemistry|December 11, 2002
A two-drug model for etoposide action against human topoisomerase IIalphaKenneth D Bromberg, Alex B Burgin, Neil Osheroff
Biochemistry|May 19, 2021
Topoisomerase II Poisons: Converting Essential Enzymes into Molecular ScissorsKendra R Vann, Alexandria A Oviatt, Neil Osheroff
Nucleic Acids Research|July 26, 2008
Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavageJoseph E Deweese, Alex B Burgin, Neil Osheroff
Journal of Molecular Biology|June 4, 2026
Novel Bacterial Topoisomerase Inhibitors: A New Front in an Old WarChelsea A Mann, James M Dewar, Neil Osheroff
Chemical Research in Toxicology|March 22, 2013
Epimerization of green tea catechins during brewing does not affect the ability to poison human type II topoisomerasesM Anne Timmel, Jo Ann W Byl, Neil Osheroff
Biochemistry|January 21, 2004
Cobalt enhances DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cellsErin L Baldwin, Jo Ann Wilson Byl, Neil Osheroff
Biochemistry|November 16, 2005
DNA methylation impacts the cleavage activity of Chlorella virus topoisomerase IIJennifer S Dickey, James L Van Etten, Neil Osheroff
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