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Samuel J Goodchild

Showing results (21-30 of 28) with videos related to

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BMC Neurology|January 17, 2024
Expanding the genotype-phenotype spectrum in SCN8A-related disordersMalavika Hebbar, Nawaf Al-Taweel, Inderpal Gill, et al.
ACS Chemical Neuroscience|February 15, 2024
Molecular Pharmacology of Selective Na<sub>V</sub>1.6 and Dual Na<sub>V</sub>1.6/Na<sub>V</sub>1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex VivoSamuel J Goodchild, Noah Gregory Shuart, Aaron D Williams, et al.
Bioorganic & Medicinal Chemistry Letters|May 27, 2021
Identification of aryl sulfonamides as novel and potent inhibitors of Na<sub>V</sub>1.5Shaoyi Sun, Qi Jia, Alla Y Zenova, et al.
Cell Reports|September 21, 2018
Selective Na<sub>V</sub>1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic PainGirish Bankar, Samuel J Goodchild, Sarah Howard, et al.
Journal of Medicinal Chemistry|September 19, 2019
Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective Na<sub>V</sub>1.6 Inhibitors with Efficacy in Mouse Models of EpilepsyThilo Focken, Kristen Burford, Michael E Grimwood, et al.
British Journal of Pharmacology|June 26, 2024
The contribution of Na<sub>V</sub>1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and Na<sub>V</sub>1.6 gain-of-function (GOF) mouse seizure controlJames P Johnson, Thilo Focken, Parisa Karimi Tari, et al.
Journal of Medicinal Chemistry|May 9, 2018
Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNa<sub>V</sub>1.7 Inhibitors for the Treatment of PainThilo Focken, Sultan Chowdhury, Alla Zenova, et al.
Elife|March 2, 2022
NBI-921352, a first-in-class, Na<sub>V</sub>1.6 selective, sodium channel inhibitor that prevents seizures in <i>Scn8a</i> gain-of-function mice, and wild-type mice and ratsJ P Johnson, Thilo Focken, Kuldip Khakh, et al.
Pageof 3

Showing results (21-30 of 28) with videos related to

Sort By:
Pageof 3
You have reached the last page of results.This site can display upto 28 results.
BMC Neurology|January 17, 2024
Expanding the genotype-phenotype spectrum in SCN8A-related disordersMalavika Hebbar, Nawaf Al-Taweel, Inderpal Gill, et al.
ACS Chemical Neuroscience|February 15, 2024
Molecular Pharmacology of Selective Na<sub>V</sub>1.6 and Dual Na<sub>V</sub>1.6/Na<sub>V</sub>1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex VivoSamuel J Goodchild, Noah Gregory Shuart, Aaron D Williams, et al.
Bioorganic & Medicinal Chemistry Letters|May 27, 2021
Identification of aryl sulfonamides as novel and potent inhibitors of Na<sub>V</sub>1.5Shaoyi Sun, Qi Jia, Alla Y Zenova, et al.
Cell Reports|September 21, 2018
Selective Na<sub>V</sub>1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic PainGirish Bankar, Samuel J Goodchild, Sarah Howard, et al.
Journal of Medicinal Chemistry|September 19, 2019
Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective Na<sub>V</sub>1.6 Inhibitors with Efficacy in Mouse Models of EpilepsyThilo Focken, Kristen Burford, Michael E Grimwood, et al.
British Journal of Pharmacology|June 26, 2024
The contribution of Na<sub>V</sub>1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and Na<sub>V</sub>1.6 gain-of-function (GOF) mouse seizure controlJames P Johnson, Thilo Focken, Parisa Karimi Tari, et al.
Journal of Medicinal Chemistry|May 9, 2018
Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNa<sub>V</sub>1.7 Inhibitors for the Treatment of PainThilo Focken, Sultan Chowdhury, Alla Zenova, et al.
Elife|March 2, 2022
NBI-921352, a first-in-class, Na<sub>V</sub>1.6 selective, sodium channel inhibitor that prevents seizures in <i>Scn8a</i> gain-of-function mice, and wild-type mice and ratsJ P Johnson, Thilo Focken, Kuldip Khakh, et al.
Pageof 3