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Journal of Medicinal Chemistry|October 27, 2017
Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft ModelKevin R Fales, F George Njoroge, Harold B Brooks, et al.
The Journal of Clinical Investigation|September 6, 2007
Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicityJeremy R Graff, Bruce W Konicek, Thomas M Vincent, et al.
Scientific Reports|October 20, 2018
Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine modelsHarold B Brooks, Timothy I Meier, Sandaruwan Geeganage, et al.
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