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Journal of Medicinal Chemistry|February 1, 2017
Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in HumansAtli Thorarensen, Martin E Dowty, Mary Ellen Banker, et al.The Journal of Pharmacology and Experimental Therapeutics|May 4, 2023
A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin InflammationWei Li, Kimberly K Crouse, Jennifer Alley, et al.Journal of Medicinal Chemistry|December 30, 2021
Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1Agustin Casimiro-Garcia, Christophe Allais, Agnes Brennan, et al.Nature Communications|May 16, 2025
Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca2+ dependent allosteric binding siteLeslie A Dakin, Li Xing, Justin Hall, et al.Scientific Reports|August 17, 2016
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonistsShenping Liu, Leslie A Dakin, Li Xing, et al.Plos One|September 22, 2017
Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assayJustin Hall, Amy Brault, Fabien Vincent, et al.ACS Chemical Biology|October 30, 2016
Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective InhibitionJean-Baptiste Telliez, Martin E Dowty, Lu Wang, et al.Nature Communications|August 31, 2024
Structural basis for CCR6 modulation by allosteric antagonistsDavid Jonathan Wasilko, Brian S Gerstenberger, Kathleen A Farley, et al.Journal of Medicinal Chemistry|August 17, 2018
Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)Andrew Fensome, Catherine M Ambler, Eric Arnold, et al.Nature Communications|March 10, 2026
Discovery of an ITK and TRK kinase inhibitor for the potential topical treatment of atopic dermatitisJennifer L Duffen, Kimberly K Crouse, Lin Ji, et al.Pageof 7