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Journal of Medicinal Chemistry|September 22, 2025
Discovery of PF-07054894, a Potent Squaramide-Based CCR6 Antagonist Displaying High CXCR2 SelectivityMark E Schnute, Huixian Wu, John I Trujillo, et al.
ACS Medicinal Chemistry Letters|August 20, 2025
Peptidylarginine Deiminase (PAD) Inhibitor Optimization through Displacement of a Trapped Water MoleculeMark E Schnute, Gary M Chinigo, Kentaro Futatsugi, et al.
Journal of Medicinal Chemistry|May 13, 2017
Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug DesignKatherine L Lee, Catherine M Ambler, David R Anderson, et al.
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