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Clinical Pharmacology in Drug Development|May 1, 2023
A Phase 1 First-in-Human Pharmacokinetic and Pharmacodynamic Study of JNJ-64264681, a Covalent Inhibitor of Bruton's Tyrosine KinaseJocelyn H Leu, Xin Miao, Kevin Shalayda, et al.
Bioorganic & Medicinal Chemistry Letters|October 16, 2010
Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonistsNatalie A Hawryluk, Jeffrey E Merit, Alec D Lebsack, et al.
The New England Journal of Medicine|December 12, 2024
Bedaquiline Monotherapy for Multibacillary LeprosyJaison Barreto, Patricia Sammarco Rosa, Linda Adams, et al.
The Journal of Pharmacology and Experimental Therapeutics|July 17, 2015
Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of InsomniaPascal Bonaventure, Jonathan Shelton, Sujin Yun, et al.
Bioorganic & Medicinal Chemistry Letters|November 29, 2008
Identification and synthesis of 2,7-diamino-thiazolo[5,4-d]pyrimidine derivatives as TRPV1 antagonistsAlec D Lebsack, Bryan J Branstetter, Michael D Hack, et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience|March 25, 2005
Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer painJoseph R Ghilardi, Heidi Röhrich, Theodore H Lindsay, et al.
ACS Medicinal Chemistry Letters|December 30, 2015
Preclinical Characterization of the FAAH Inhibitor JNJ-42165279John M Keith, William M Jones, Mark Tichenor, et al.
Bioorganic & Medicinal Chemistry Letters|February 12, 2014
1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolaseJohn M Keith, Natalie Hawryluk, Richard L Apodaca, et al.
Bioorganic & Medicinal Chemistry Letters|January 18, 2014
Heteroarylureas with spirocyclic diamine cores as inhibitors of fatty acid amide hydrolaseJohn M Keith, William M Jones, Joan M Pierce, et al.
Bioorganic & Medicinal Chemistry Letters|May 19, 2016
The SAR of brain penetration for a series of heteroaryl urea FAAH inhibitorsJohn M Keith, Mark S Tichenor, Richard L Apodaca, et al.
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