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Molecular Cancer Research : MCR|July 29, 2015
Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP InhibitorsTodd A Hopkins, Yan Shi, Luis E Rodriguez, et al.Molecular Cancer Therapeutics|March 30, 2018
ABT-165, a Dual Variable Domain Immunoglobulin (DVD-Ig) Targeting DLL4 and VEGF, Demonstrates Superior Efficacy and Favorable Safety Profiles in Preclinical ModelsYingchun Li, Jonathan A Hickson, Dominic J Ambrosi, et al.Journal of Medicinal Chemistry|April 2, 2019
Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) StabilizerAndrew M Petros, Alla Korepanova, Clarissa G Jakob, et al.Molecular Cancer Therapeutics|February 9, 2026
Microsatellite instable cancer cells acquire on-target resistance mutations to WRN helicase inhibitorsFaith Fowler, Jessica Gajda, Amirhossein Mafi, et al.ACS Chemical Biology|February 21, 2022
The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for ImmunotherapySven Malchow, Alla Korepanova, Sanjay C Panchal, et al.Molecular Cancer Therapeutics|February 28, 2018
Characterization of ABBV-221, a Tumor-Selective EGFR-Targeting Antibody Drug ConjugateAndrew C Phillips, Erwin R Boghaert, Kedar S Vaidya, et al.Scientific Reports|August 26, 2022
Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal siteEric R Goedken, Maria A Argiriadi, Justin D Dietrich, et al.The Journal of Pharmacology and Experimental Therapeutics|March 24, 2025
Small molecule interleukin (IL) 17A/A antagonists and antibodies blocking both IL17A/A and IL17A/F demonstrate equivalent degrees of efficacy in preclinical models of skin and joint inflammationEric R Goedken, Zhi Su, Alex Lipovsky, et al.Journal of Medicinal Chemistry|March 6, 2023
Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In VivoJohn T Randolph, Matthew J O'Connor, Fei Han, et al.Journal of Medicinal Chemistry|June 5, 2025
Validation, Key Pharmacophores, and X-ray Cocrystal Structures of Novel Biochemically and Cellularly Active WRN Inhibitors Derived from a DNA-Encoded Library ScreenYunsong Tong, Kenton A Baker, Alex M Chapman, et al.Pageof 3