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Journal of Medicinal Chemistry|December 30, 2020
Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug DesignJustin D Dietrich, Kenton L Longenecker, Noel S Wilson, et al.Molecular Cancer Therapeutics|March 20, 2024
Inhibition of MALT1 and BCL2 Induces Synergistic Antitumor Activity in Models of B-Cell LymphomaJoshua P Plotnik, Adam E Richardson, Haopeng Yang, et al.Bioorganic & Medicinal Chemistry Letters|March 8, 2017
Methylpyrrole inhibitors of BET bromodomainsLisa A Hasvold, George S Sheppard, Le Wang, et al.Nature|January 24, 2020
Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancerEmily J Faivre, Keith F McDaniel, Daniel H Albert, et al.Journal of Medicinal Chemistry|April 4, 2017
Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain InhibitorsLe Wang, John K Pratt, Todd Soltwedel, et al.Nature Chemical Biology|January 31, 2017
The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complexYupeng He, Sujatha Selvaraju, Michael L Curtin, et al.Journal of Medicinal Chemistry|May 25, 2026
Discovery of Potent and Orally Bioavailable Novel Cluster of Differentiation 38 (CD38) Small Molecule InhibitorsReza Shiroodi, Timothy J Montavon, Brandon M Nelson, et al.Journal of Medicinal Chemistry|April 4, 2024
Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active CompoundsAshley L Ramos, Eric R Goedken, Kristine E Frank, et al.Pageof 3