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Bioorganic & Medicinal Chemistry|September 19, 2025
Generation of a potent & selective series of IRAK4 inhibitors based on a structure based, hybridization approachIna Terstiege, Anna Aagaard, Kristina Berggren, et al.Journal of Medicinal Chemistry|December 5, 2025
Spirocyclopentane as a Novel Scaffold for Potent Ghrelin Receptor Full AgonistsCristina Gardelli, Antonio Llinas, Igor Shamovsky, et al.Journal of Medicinal Chemistry|August 14, 2020
Identification and Optimization of Pyrrolidine Derivatives as Highly Potent Ghrelin Receptor Full AgonistsMartin Cooper, Antonio Llinas, Peter Hansen, et al.ACS Medicinal Chemistry Letters|June 17, 2026
Discovery of a Selective Histone Deacetylase 6 Degrader (HDAC6 PROTAC) with a Short and Rigid Linker Demonstrating Sustained Knockdown of HDAC6 In VivoLena Ripa, Carlo Cassani, Glyn Hughes, et al.Plos One|January 1, 2016
Novel Zn2+ Modulated GPR39 Receptor Agonists Do Not Drive Acute Insulin Secretion in RodentsOla Fjellström, Niklas Larsson, Shin-Ichiro Yasuda, et al.Diabetes, Obesity & Metabolism|November 4, 2024
Non-clinical and first-in-human characterization of ECC5004/AZD5004, a novel once-daily, oral small-molecule GLP-1 receptor agonistAmina Z Haggag, Jianfeng Xu, Laurie Butcher, et al.The Journal of Pharmacology and Experimental Therapeutics|September 28, 2025
Preclinical evaluation and first-in-human phase 1 trial of AZD0186, a novel, oral small molecule glucagon-like peptide-1 receptor agonistWeier Qi, Simina M Boca, Alessandro Boianelli, et al.Pageof 2