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The Journal of Biological Chemistry|June 14, 2003
The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 productionSarah A Sagi, Sascha Weggen, Jason Eriksen, et al.
The Journal of Biological Chemistry|June 5, 2003
Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domainSascha Weggen, Jason L Eriksen, Sarah A Sagi, et al.
The Journal of Biological Chemistry|June 14, 2003
Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activitySascha Weggen, Jason L Eriksen, Sarah A Sagi, et al.
Journal of Neurochemistry|September 28, 2004
Rho-mediated cytoskeletal rearrangement in response to LPA is functionally antagonized by Rac1 and PIP2Tammy M Seasholtz, Julie Radeff-Huang, Sarah A Sagi, et al.
The Journal of Biological Chemistry|August 27, 2011
Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor proteinSarah A Sagi, Christian B Lessard, Kellen D Winden, et al.
Proceedings of the National Academy of Sciences of the United States of America|April 28, 2006
Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664Veronica Galvan, Olivia F Gorostiza, Surita Banwait, et al.
Journal of Neurochemistry|November 23, 2005
Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42Stefanie Leuchtenberger, Markus P Kummer, Thomas Kukar, et al.
The Journal of Clinical Investigation|August 5, 2003
NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivoJason L Eriksen, Sarah A Sagi, Tawnya E Smith, et al.
Alzheimer Disease and Associated Disorders|December 20, 2007
Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individualsDouglas R Galasko, Neil Graff-Radford, Susanne May, et al.
Nature Medicine|April 19, 2005
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 productionThomas Kukar, Michael Paul Murphy, Jason L Eriksen, et al.
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