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Journal of Medicinal Chemistry|May 28, 2010
Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activityMartina Hieke, Julia Ness, Ramona Steri, et al.Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism|February 2, 2012
Cellular prion protein participates in amyloid-β transcytosis across the blood-brain barrierThorsten Pflanzner, Benjamin Petsch, Bettina André-Dohmen, et al.Journal of Neurochemistry|November 25, 2010
Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structureStefanie Hahn, Tanja Brüning, Julia Ness, et al.Brain, Behavior, and Immunity|July 25, 2018
The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALMSteffen E Storck, Anika M S Hartz, Jessica Bernard, et al.Bioorganic & Medicinal Chemistry Letters|February 22, 2018
Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitorsParul Goel, Thorsten Jumpertz, Anežka Tichá, et al.Neurobiology of Aging|September 28, 2011
No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's diseaseAntje Hillmann, Stefanie Hahn, Stephan Schilling, et al.Neurobiology of Aging|July 16, 2010
LRP1 mediates bidirectional transcytosis of amyloid-β across the blood-brain barrierThorsten Pflanzner, Maren C Janko, Bettina André-Dohmen, et al.Alzheimer'S Research & Therapy|October 6, 2017
N-truncated Aβ4-x peptides in sporadic Alzheimer's disease cases and transgenic Alzheimer mouse modelsOliver Wirths, Susanne Walter, Inga Kraus, et al.ACS Chemical Biology|June 26, 2012
Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screeningHeiko Zettl, Julia Ness, Volker Hähnke, et al.Experimental Cell Research|November 28, 2015
Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migrationVerena K Rabiej, Thorsten Pflanzner, Timo Wagner, et al.Pageof 8