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Proceedings of the National Academy of Sciences of the United States of America|August 4, 2010
Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerizationLuise Richter, Lisa-Marie Munter, Julia Ness, et al.
Molecular Neurodegeneration|February 21, 2016
Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage siteCaroline Schönherr, Jessica Bien, Simone Isbert, et al.
Cellular and Molecular Life Sciences : CMLS|March 2, 2022
Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's diseaseLiana Marengo, Fred Armbrust, Caroline Schoenherr, et al.
Journal of Neurochemistry|November 23, 2005
Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42Stefanie Leuchtenberger, Markus P Kummer, Thomas Kukar, et al.
The Journal of Clinical Investigation|August 5, 2003
NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivoJason L Eriksen, Sarah A Sagi, Tawnya E Smith, et al.
Scientific Reports|December 3, 2015
Alzheimer therapy with an antibody against N-terminal Abeta 4-X and pyroglutamate Abeta 3-XGregory Antonios, Henning Borgers, Bernhard C Richard, et al.
Neuropathology and Applied Neurobiology|June 12, 2024
Amino-terminally elongated Aβ peptides are generated by the secreted metalloprotease ADAMTS4 and deposit in a subset of Alzheimer's disease brainsOliver Wirths, Christina Lehnen, Merle Fricke, et al.
Alzheimer'S Research & Therapy|November 28, 2013
Nanoparticulate flurbiprofen reduces amyloid-β42 generation in an in vitro blood-brain barrier modelSabrina Meister, Iavor Zlatev, Julia Stab, et al.
JCI Insight|September 6, 2019
Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cellsAnfei Huang, Prashant V Shinde, Jun Huang, et al.
Biochemistry|November 30, 2017
Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane ProteasesParul Goel, Thorsten Jumpertz, David C Mikles, et al.
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