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The Journal of Biological Chemistry|October 4, 2007
Active gamma-secretase complexes contain only one of each componentToru Sato, Thekla S Diehl, Saravanakumar Narayanan, et al.
The Journal of Biological Chemistry|April 24, 2008
Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment betaMasafumi Shimojo, Naruhiko Sahara, Tatsuya Mizoroki, et al.
Structure (London, England : 1993)|December 19, 2025
γ-Secretase exosites as targets for substrate-selective lowering of Aβ generationRiki Maruyama, Akio Fukumori, Satoru Funamoto, et al.
Biochemical and Biophysical Research Communications|December 19, 2020
A potential defense mechanism against amyloid deposition in cerebellumAlam Shahnur, Masaki Nakano, Seiko Ishihara, et al.
Nature Communications|October 11, 2013
Substrate ectodomain is critical for substrate preference and inhibition of γ-secretaseSatoru Funamoto, Toru Sasaki, Seiko Ishihara, et al.
Genes to Cells : Devoted to Molecular & Cellular Mechanisms|December 6, 2017
Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagyKentaro Shimasaki, Miho Watanabe-Takahashi, Masato Umeda, et al.
Nature Neuroscience|July 5, 2011
Potent amyloidogenicity and pathogenicity of Aβ43Takashi Saito, Takahiro Suemoto, Nathalie Brouwers, et al.
Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society|September 24, 2010
The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallelKohji Mori, Masayasu Okochi, Shinji Tagami, et al.
Communications Biology|April 8, 2023
A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregationWaka Sato, Miho Watanabe-Takahashi, Takuya Murata, et al.
The Journal of Biological Chemistry|June 1, 2013
Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3Min Suk Kang, Seung-Hoon Baek, Yoon Sun Chun, et al.
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