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Journal of the American Chemical Society|March 20, 2026
Stereodivergent Construction of trans-Decalin-Based TerpenoidsSamantha L Barlock, Alexander S Shved, Kayla D Landers, et al.
Journal of Medicinal Chemistry|February 1, 2017
Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in HumansAtli Thorarensen, Martin E Dowty, Mary Ellen Banker, et al.
The Journal of Pharmacology and Experimental Therapeutics|May 4, 2023
A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+ T Cells, and Ameliorates Interleukin-23-Induced Skin InflammationWei Li, Kimberly K Crouse, Jennifer Alley, et al.
Scientific Reports|August 17, 2016
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonistsShenping Liu, Leslie A Dakin, Li Xing, et al.
ACS Chemical Biology|October 30, 2016
Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective InhibitionJean-Baptiste Telliez, Martin E Dowty, Lu Wang, et al.
Nature Communications|August 31, 2024
Structural basis for CCR6 modulation by allosteric antagonistsDavid Jonathan Wasilko, Brian S Gerstenberger, Kathleen A Farley, et al.
ACS Medicinal Chemistry Letters|June 6, 2014
Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS)Chris P Carron, John I Trujillo, Kirk L Olson, et al.
Journal of Medicinal Chemistry|September 22, 2025
Discovery of PF-07054894, a Potent Squaramide-Based CCR6 Antagonist Displaying High CXCR2 SelectivityMark E Schnute, Huixian Wu, John I Trujillo, et al.
Journal of Medicinal Chemistry|August 22, 2018
Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse AgonistMark E Schnute, Mattias Wennerstål, Jennifer Alley, et al.
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