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Journal of Pharmacokinetics and Pharmacodynamics|January 30, 2017
Population pharmacokinetics and pharmacodynamics of IONIS-GCGRRx, an antisense oligonucleotide for type 2 diabetes mellitus: a red blood cell lifespan modelKenneth T Luu, Erin S Morgan, Sanjay Bhanot, et al.British Journal of Clinical Pharmacology|July 23, 2022
Population pharmacokinetic/pharmacodynamic modelling of eplontersen, an antisense oligonucleotide in development for transthyretin amyloidosisJohn K Diep, Rosie Z Yu, Nicholas J Viney, et al.Journal of Clinical Pharmacology|July 8, 2022
Assessment of the Effect of Organ Impairment on the Pharmacokinetics of 2'-MOE and Phosphorothioate Modified Antisense OligonucleotidesYanfeng Wang, John K Diep, Rosie Z Yu, et al.Journal of Thrombosis and Haemostasis : JTH|August 18, 2024
CpG oligonucleotides induce acute murine thrombocytopenia dependent on toll-like receptor 9 and spleen tyrosine kinase pathwaysKarl Johansson, Amal Maouia, Johan Rebetz, et al.Nucleic Acid Therapeutics|November 11, 2017
Impurities in Oligonucleotide Drug Substances and Drug ProductsDaniel Capaldi, Andy Teasdale, Scott Henry, et al.CPT: Pharmacometrics & Systems Pharmacology|July 26, 2018
A Semi-Mechanistic Population Pharmacokinetic Model of Nusinersen: An Antisense Oligonucleotide for the Treatment of Spinal Muscular AtrophyKonstantinos Biliouris, Puneet Gaitonde, Wei Yin, et al.Nucleic Acid Therapeutics|June 13, 2017
The Distinct and Cooperative Roles of Toll-Like Receptor 9 and Receptor for Advanced Glycation End Products in Modulating In Vivo Inflammatory Responses to Select CpG and Non-CpG OligonucleotidesSuzanne Paz, Jill Hsiao, Patrick Cauntay, et al.Nucleic Acid Therapeutics|November 25, 2024
A Combined Fertility and Developmental Toxicity Study with an Antisense Oligonucleotide Targeting Murine Apolipoprotein C-III mRNA in MiceJi-Seong Jeong, Archit Rastogi, Tae-Won Kim, et al.Molecular Therapy. Nucleic Acids|May 4, 2016
Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in MiceRosie Z Yu, Mark J Graham, Noah Post, et al.Nucleic Acids Research|February 3, 2026
Transient acute neuronal activation response caused by high concentrations of oligonucleotides in the cerebral spinal fluidMariana Bravo-Hernandez, Curt Mazur, Hao Chen, et al.Pageof 3