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Nature Communications|October 12, 2017
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradationChiara Maniaci, Scott J Hughes, Andrea Testa, et al.ACS Medicinal Chemistry Letters|September 17, 2020
Understanding and Improving the Membrane Permeability of VH032-Based PROTACsVictoria G Klein, Chad E Townsend, Andrea Testa, et al.Nature Chemical Biology|November 4, 2022
Functional E3 ligase hotspots and resistance mechanisms to small-molecule degradersAlexander Hanzl, Ryan Casement, Hana Imrichova, et al.Journal of Medicinal Chemistry|December 13, 2018
Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7Vittoria Zoppi, Scott J Hughes, Chiara Maniaci, et al.ACS Infectious Diseases|October 21, 2016
Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the ProductScott J Hughes, Leanne Barnard, Katayoun Mottaghi, et al.Nature Chemical Biology|October 22, 2021
Trivalent PROTACs enhance protein degradation via combined avidity and cooperativitySatomi Imaide, Kristin M Riching, Nikolai Makukhin, et al.Nature Communications|October 28, 2025
Mode of action of a DCAF16-recruiting targeted glue that can selectively degrade BRD9Scott J Hughes, Wojciech J Stec, Colin T R Davies, et al.Pageof 2