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Journal of Medicinal Chemistry|March 11, 2024
Development of a Series of Pyrrolopyridone MAT2A InhibitorsStephen J Atkinson, Sharan K Bagal, Argyrides Argyrou, et al.Journal of Medicinal Chemistry|November 12, 2019
Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC)Richard A Ward, Mark J Anderton, Paul Bethel, et al.Journal of Medicinal Chemistry|February 6, 2020
Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12CJason G Kettle, Sharan K Bagal, Sue Bickerton, et al.Journal of Medicinal Chemistry|July 31, 2024
Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA CooperativityJames M Smith, Bernard Barlaam, David Beattie, et al.Journal of Medicinal Chemistry|April 26, 2022
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12CJason G Kettle, Sharan K Bagal, Sue Bickerton, et al.Journal of Medicinal Chemistry|July 3, 2023
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS PenetrationJason G Kettle, Sharan K Bagal, Derek Barratt, et al.Journal of Medicinal Chemistry|September 3, 2025
Discovery of AZD8421: A Potent CDK2 Inhibitor with Selectivity Against Other CDK Family Members and the Human KinomeAvipsa Ghosh, Afshan Ahmed, Konstantina Amoiradaki, et al.Journal of Medicinal Chemistry|February 10, 2025
Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 InhibitorJason D Shields, David Baker, Amber Y S Balazs, et al.Pageof 7