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Nature Genetics
|
October 24, 2024
Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification
Simone M Haag, Shiqi Xie, Celine Eidenschenk, et al.
Plos Neglected Tropical Diseases
|
April 14, 2017
The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection
Elizabeth A Nelson, Julie Dyall, Thomas Hoenen, et al.
Science Translational Medicine
|
October 25, 2023
DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity
Michael Wichroski, Joseph Benci, Si-Qi Liu, et al.
Journal of Medicinal Chemistry
|
August 13, 2013
Structure- and reactivity-based development of covalent inhibitors of the activating and gatekeeper mutant forms of the epidermal growth factor receptor (EGFR)
Richard A Ward, Mark J Anderton, Susan Ashton, et al.
JCI Insight
|
July 21, 2020
Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections
Kenneth E Remy, Monty Mazer, David A Striker, et al.
Neuron
|
March 27, 2026
Microglia-mediated protection against Alzheimer's disease pathology and detrimental effects in white matter revealed by Ptpn6 deletion
Ainhoa Etxeberria, Seung-Hye Lee, Julia A Kuhn, et al.
Nature Communications
|
November 10, 2022
Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers
Jennifer Cantley, Xiaofen Ye, Emma Rousseau, et al.
Journal of Medicinal Chemistry
|
June 30, 2012
(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis
Alexander G Dossetter, Howard Beeley, Jonathan Bowyer, et al.
Journal of Medicinal Chemistry
|
September 28, 2024
Optimization of Potent, Efficacious, Selective and Blood-Brain Barrier Penetrating Inhibitors Targeting EGFR Exon20 Insertion Mutations
Clare Thomson, Erin Braybrooke, Nicola Colclough, et al.
Communications Biology
|
May 13, 2024
Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC
Thomas G Hayhow, Beth Williamson, Mandy Lawson, et al.
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Search research articles
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Showing results (221-230 of 241) with videos related to
Sort By:
Page
of 25
Nature Genetics
|
October 24, 2024
Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification
Simone M Haag, Shiqi Xie, Celine Eidenschenk, et al.
Plos Neglected Tropical Diseases
|
April 14, 2017
The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection
Elizabeth A Nelson, Julie Dyall, Thomas Hoenen, et al.
Science Translational Medicine
|
October 25, 2023
DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity
Michael Wichroski, Joseph Benci, Si-Qi Liu, et al.
Journal of Medicinal Chemistry
|
August 13, 2013
Structure- and reactivity-based development of covalent inhibitors of the activating and gatekeeper mutant forms of the epidermal growth factor receptor (EGFR)
Richard A Ward, Mark J Anderton, Susan Ashton, et al.
JCI Insight
|
July 21, 2020
Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections
Kenneth E Remy, Monty Mazer, David A Striker, et al.
Neuron
|
March 27, 2026
Microglia-mediated protection against Alzheimer's disease pathology and detrimental effects in white matter revealed by Ptpn6 deletion
Ainhoa Etxeberria, Seung-Hye Lee, Julia A Kuhn, et al.
Nature Communications
|
November 10, 2022
Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers
Jennifer Cantley, Xiaofen Ye, Emma Rousseau, et al.
Journal of Medicinal Chemistry
|
June 30, 2012
(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis
Alexander G Dossetter, Howard Beeley, Jonathan Bowyer, et al.
Journal of Medicinal Chemistry
|
September 28, 2024
Optimization of Potent, Efficacious, Selective and Blood-Brain Barrier Penetrating Inhibitors Targeting EGFR Exon20 Insertion Mutations
Clare Thomson, Erin Braybrooke, Nicola Colclough, et al.
Communications Biology
|
May 13, 2024
Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC
Thomas G Hayhow, Beth Williamson, Mandy Lawson, et al.
Page
of 25