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Cancer Letters|March 6, 2012
Combined inhibition of EGFR and CK2 augments the attenuation of PI3K-Akt-mTOR signaling and the killing of cancer cellsJoshua Bliesath, Nanni Huser, Mayuko Omori, et al.
Cancer Research|December 17, 2010
CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacyAdam Siddiqui-Jain, Denis Drygin, Nicole Streiner, et al.
Bioorganic & Medicinal Chemistry Letters|December 16, 2011
Synthesis and SAR of inhibitors of protein kinase CK2: novel tricyclic quinoline analogsMustapha Haddach, Fabrice Pierre, Collin F Regan, et al.
Molecular Cancer Therapeutics|January 24, 2012
CK2 inhibitor CX-4945 suppresses DNA repair response triggered by DNA-targeted anticancer drugs and augments efficacy: mechanistic rationale for drug combination therapyAdam Siddiqui-Jain, Joshua Bliesath, Diwata Macalino, et al.
ACS Medicinal Chemistry Letters|June 6, 2014
Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer TherapeuticsMustapha Haddach, Michael K Schwaebe, Jerome Michaux, et al.
Cancer Research|December 17, 2010
Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growthDenis Drygin, Amy Lin, Josh Bliesath, et al.
ACS Medicinal Chemistry Letters|June 6, 2014
Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases InhibitorMustapha Haddach, Jerome Michaux, Michael K Schwaebe, et al.
Journal of Medicinal Chemistry|December 23, 2010
Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancerFabrice Pierre, Peter C Chua, Sean E O'Brien, et al.
Molecular and Cellular Biochemistry|July 15, 2011
Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancerFabrice Pierre, Peter C Chua, Sean E O'Brien, et al.
Nature Materials|April 22, 2014
Scalable production of large quantities of defect-free few-layer graphene by shear exfoliation in liquidsKeith R Paton, Eswaraiah Varrla, Claudia Backes, et al.
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