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Sean M Smith

Showing results (41-50 of 56) with videos related to

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Neurobiology of Disease|September 12, 2021
A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathyMali Cosden, Sarah Jinn, Lihang Yao, et al.
Bioorganic & Medicinal Chemistry Letters|March 15, 2018
Indole acids as a novel PDE2 inhibitor chemotype that demonstrate pro-cognitive activity in multiple speciesShawn J Stachel, Melissa S Egbertson, Jenny Wai, et al.
Bioorganic & Medicinal Chemistry Letters|May 3, 2016
Synthesis and optimization of N-heterocyclic pyridinones as catechol-O-methyltransferase (COMT) inhibitorsZhijian Zhao, Scott T Harrison, Jeffrey W Schubert, et al.
Bioorganic & Medicinal Chemistry Letters|June 17, 2015
Discovery of [¹¹C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitorsChristopher D Cox, Eric D Hostetler, Broc A Flores, et al.
The Journal of Pharmacology and Experimental Therapeutics|December 18, 2008
The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serineSean M Smith, Jason M Uslaner, Lihang Yao, et al.
Journal of Medicinal Chemistry|January 10, 2023
Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of SchizophreniaMark E Layton, Jeffrey C Kern, Timothy J Hartingh, et al.
Bioorganic & Medicinal Chemistry Letters|November 9, 2017
The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug designAshley B Forster, Pravien Abeywickrema, Jaime Bunda, et al.
Bioorganic & Medicinal Chemistry Letters|November 26, 2015
Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophreniaIzzat T Raheem, John D Schreier, Joy Fuerst, et al.
Molecular Imaging and Biology|November 25, 2015
Preclinical Characterization of the Phosphodiesterase 10A PET Tracer [(11)C]MK-8193Eric D Hostetler, Hong Fan, Aniket D Joshi, et al.
Chemmedchem|March 29, 2019
Discovery, Optimization, and Biological Characterization of 2,3,6-Trisubstituted Pyridine-Containing M<sub>4</sub> Positive Allosteric ModulatorsJeffrey W Schubert, Scott T Harrison, James Mulhearn, et al.
Pageof 6

Showing results (41-50 of 56) with videos related to

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Pageof 6
Neurobiology of Disease|September 12, 2021
A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathyMali Cosden, Sarah Jinn, Lihang Yao, et al.
Bioorganic & Medicinal Chemistry Letters|March 15, 2018
Indole acids as a novel PDE2 inhibitor chemotype that demonstrate pro-cognitive activity in multiple speciesShawn J Stachel, Melissa S Egbertson, Jenny Wai, et al.
Bioorganic & Medicinal Chemistry Letters|May 3, 2016
Synthesis and optimization of N-heterocyclic pyridinones as catechol-O-methyltransferase (COMT) inhibitorsZhijian Zhao, Scott T Harrison, Jeffrey W Schubert, et al.
Bioorganic & Medicinal Chemistry Letters|June 17, 2015
Discovery of [¹¹C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitorsChristopher D Cox, Eric D Hostetler, Broc A Flores, et al.
The Journal of Pharmacology and Experimental Therapeutics|December 18, 2008
The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serineSean M Smith, Jason M Uslaner, Lihang Yao, et al.
Journal of Medicinal Chemistry|January 10, 2023
Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of SchizophreniaMark E Layton, Jeffrey C Kern, Timothy J Hartingh, et al.
Bioorganic & Medicinal Chemistry Letters|November 9, 2017
The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug designAshley B Forster, Pravien Abeywickrema, Jaime Bunda, et al.
Bioorganic & Medicinal Chemistry Letters|November 26, 2015
Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophreniaIzzat T Raheem, John D Schreier, Joy Fuerst, et al.
Molecular Imaging and Biology|November 25, 2015
Preclinical Characterization of the Phosphodiesterase 10A PET Tracer [(11)C]MK-8193Eric D Hostetler, Hong Fan, Aniket D Joshi, et al.
Chemmedchem|March 29, 2019
Discovery, Optimization, and Biological Characterization of 2,3,6-Trisubstituted Pyridine-Containing M<sub>4</sub> Positive Allosteric ModulatorsJeffrey W Schubert, Scott T Harrison, James Mulhearn, et al.
Pageof 6