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Sean W Fanning

Showing results (21-30 of 37) with videos related to

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ACS Pharmacology & Translational Science|August 14, 2025
Benzestrol Isomer Stereochemistry Determines the Distinct Estrogenic Activities and Conformations of the Eight Isomers When Bound to Estrogen Receptor αYingwei Hou, Jerome C Nwachukwu, Kathryn Carlson, et al.
JCI Insight|May 6, 2025
Imlunestrant a next-generation oral SERD overcomes ESR1 mutant resistance in estrogen receptor-positive breast cancerShira Sherman, Zachary M Sandusky, Douglas Russo, et al.
Elife|May 16, 2022
Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in <i>ESR1</i> mutant breast cancer cellsDavid J Hosfield, Sandra Weber, Nan-Sheng Li, et al.
Elife|February 3, 2016
Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformationSean W Fanning, Christopher G Mayne, Venkatasubramanian Dharmarajan, et al.
Molecular Cancer Therapeutics|November 12, 2020
Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast CancerBalkees Abderrahman, Philipp Y Maximov, Ramona F Curpan, et al.
Molecular Pharmacology|May 5, 2020
The Structure-Function Relationship of Angular Estrogens and Estrogen Receptor Alpha to Initiate Estrogen-Induced Apoptosis in Breast Cancer CellsPhilipp Y Maximov, Balkees Abderrahman, Yousef M Hawsawi, et al.
Science Translational Medicine|June 4, 2025
Inhibition of NR2F2 restores hormone therapy response to endocrine refractory breast cancersYanyan Cai, Peihua Zhao, Fan Wu, et al.
Breast Cancer Research : BCR|January 17, 2025
Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cellsK S Young, G R Hancock, E C Fink, et al.
Science Translational Medicine|July 22, 2021
A small-molecule activator of the unfolded protein response eradicates human breast tumors in miceMatthew W Boudreau, Darjan Duraki, Lawrence Wang, et al.
Elife|November 30, 2018
The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cellsSean W Fanning, Rinath Jeselsohn, Venkatasubramanian Dharmarajan, et al.
Pageof 4

Showing results (21-30 of 37) with videos related to

Sort By:
Pageof 4
ACS Pharmacology & Translational Science|August 14, 2025
Benzestrol Isomer Stereochemistry Determines the Distinct Estrogenic Activities and Conformations of the Eight Isomers When Bound to Estrogen Receptor αYingwei Hou, Jerome C Nwachukwu, Kathryn Carlson, et al.
JCI Insight|May 6, 2025
Imlunestrant a next-generation oral SERD overcomes ESR1 mutant resistance in estrogen receptor-positive breast cancerShira Sherman, Zachary M Sandusky, Douglas Russo, et al.
Elife|May 16, 2022
Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in <i>ESR1</i> mutant breast cancer cellsDavid J Hosfield, Sandra Weber, Nan-Sheng Li, et al.
Elife|February 3, 2016
Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformationSean W Fanning, Christopher G Mayne, Venkatasubramanian Dharmarajan, et al.
Molecular Cancer Therapeutics|November 12, 2020
Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast CancerBalkees Abderrahman, Philipp Y Maximov, Ramona F Curpan, et al.
Molecular Pharmacology|May 5, 2020
The Structure-Function Relationship of Angular Estrogens and Estrogen Receptor Alpha to Initiate Estrogen-Induced Apoptosis in Breast Cancer CellsPhilipp Y Maximov, Balkees Abderrahman, Yousef M Hawsawi, et al.
Science Translational Medicine|June 4, 2025
Inhibition of NR2F2 restores hormone therapy response to endocrine refractory breast cancersYanyan Cai, Peihua Zhao, Fan Wu, et al.
Breast Cancer Research : BCR|January 17, 2025
Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cellsK S Young, G R Hancock, E C Fink, et al.
Science Translational Medicine|July 22, 2021
A small-molecule activator of the unfolded protein response eradicates human breast tumors in miceMatthew W Boudreau, Darjan Duraki, Lawrence Wang, et al.
Elife|November 30, 2018
The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cellsSean W Fanning, Rinath Jeselsohn, Venkatasubramanian Dharmarajan, et al.
Pageof 4