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Clinical and Translational Science|July 25, 2025
Proof of Pharmacology, Safety, and Pharmacokinetics of the Novel TRPA1 Antagonist BI 1839100: A Randomized, Placebo-Controlled, Parallel Group, First-In-Human Study in Healthy Male ParticipantsMarella C E van Ruissen, Sebastiaan J W van Kraaij, Jana Wolfova, et al.Clinical Physiology and Functional Imaging|September 23, 2024
Microvascular effects of a mixed meal tolerance test: a model validation studySebastiaan J W van Kraaij, Boukje Charlotte Eveleens Maarse, Femke P M Hoevenaars, et al.Clinical and Translational Science|April 29, 2023
First-in-human trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of zagociguat (CY6463), a CNS-penetrant soluble guanylyl cyclase stimulatorSebastiaan J W van Kraaij, Pim Gal, Laura G J M Borghans, et al.Experimental Dermatology|November 11, 2023
A Phase 1 randomized, open-label clinical trial to evaluate the effect of a far-infrared emitting patch on local skin perfusion, microcirculation and oxygenationSebastiaan J W van Kraaij, Michael R Hamblin, Gisele Pickering, et al.British Journal of Clinical Pharmacology|July 25, 2023
Randomized placebo-controlled crossover study to assess tolerability and pharmacodynamics of zagociguat, a soluble guanylyl cyclase stimulator, in healthy elderlySebastiaan J W van Kraaij, Laura Borghans, Erica S Klaassen, et al.Journal of Experimental Pharmacology|September 23, 2024
Open-Label Interventional Study in Healthy Volunteers to Evaluate NO-Mediated Vasodilation by Dermal Allyl Isothiocyanate Challenge and Whole-Body Heat StressMarella C E van Ruissen, Sebastiaan J W van Kraaij, Pim Gal, et al.Endoscopy International Open|August 27, 2021
Safety of low-volume PEG-asc bowel cleansing preparation for colonoscopy: identifying patients at risk for hypokalemia in a prospective cohort studyAnkie Reumkens, Christine Minke Bakker, Sebastiaan J W van Kraaij, et al.Clinical and Translational Science|May 13, 2023
Identification of peripheral vascular function measures and circulating biomarkers of mitochondrial function in patients with mitochondrial diseaseSebastiaan J W van Kraaij, Diana R Pereira, Bastiaan Smal, et al.Journal of Parkinson'S Disease|August 30, 2024
Cognitive Effects of Three β-Adrenoceptor Acting Drugs in Healthy Volunteers and Patients with Parkinson's DiseasePepijn P N M Eijsvogel, Laura G J M Borghans, Samantha Prins, et al.Nutrition, Metabolism, and Cardiovascular Diseases : NMCD|March 18, 2024
Impact of fibre supplementation on microbiome and resilience in healthy participants: A randomized, placebo-controlled clinical trialBoukje C Eveleens Maarse, Hannah M Eggink, Ines Warnke, et al.Pageof 2