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Cancers|June 24, 2022
Super-Enhancers, Phase-Separated Condensates, and 3D Genome Organization in CancerSeng Chuan Tang, Udhaya Vijayakumar, Ying Zhang, et al.Molecular Pharmaceutics|February 12, 2011
Double-transduced MDCKII cells to study human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) interplay in drug transport across the blood-brain barrierBirk Poller, Els Wagenaar, Seng Chuan Tang, et al.Current Opinion in Pharmacology|September 12, 2013
Genetically modified mouse models for oral drug absorption and dispositionSeng Chuan Tang, Jeroen J M A Hendrikx, Jos H Beijnen, et al.International Journal of Cancer|September 17, 2013
Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridarSeng Chuan Tang, Luan N Nguyen, Rolf W Sparidans, et al.The Journal of Pharmacology and Experimental Therapeutics|July 12, 2013
Impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) gene dosage on plasma pharmacokinetics and brain accumulation of dasatinib, sorafenib, and sunitinibSeng Chuan Tang, Niels de Vries, Rolf W Sparidans, et al.The Journal of Pharmacology and Experimental Therapeutics|January 13, 2012
P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict brain accumulation of the active sunitinib metabolite N-desethyl sunitinibSeng Chuan Tang, Nienke A G Lankheet, Birk Poller, et al.Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences|September 4, 2012
Liquid chromatography-tandem mass spectrometric assay for the ALK inhibitor crizotinib in mouse plasmaRolf W Sparidans, Seng Chuan Tang, Luan N Nguyen, et al.International Journal of Cancer|February 26, 2011
Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministrationSeng Chuan Tang, Jurjen S Lagas, Nienke A G Lankheet, et al.Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|April 15, 2014
P-glycoprotein, CYP3A, and plasma carboxylesterase determine brain and blood disposition of the mTOR Inhibitor everolimus (Afinitor) in miceSeng Chuan Tang, Rolf W Sparidans, Ka Lei Cheung, et al.Cancer Research|June 20, 2018
The Endosomal Protein CEMIP Links WNT Signaling to MEK1-ERK1/2 Activation in Selumetinib-Resistant Intestinal OrganoidsHong Quan Duong, Ivan Nemazanyy, Florian Rambow, et al.Pageof 2