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Biotechnology Progress|May 8, 2024
SPEED-MODE cell line development (CLD): Reducing Chinese hamster ovary (CHO) CLD timelines via earlier suspension adaptation and maximizing time spent in the exponential growth phaseKavya Ganapathy, Cynthia Lam, Joni Tsukuda, et al.
Molecular Microbiology|August 24, 2006
Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparumKaterina Artavanis-Tsakonas, Shahram Misaghi, Christy A Comeaux, et al.
Biotechnology Journal|October 30, 2024
Chromatin Accessibility Plays an Important Epigenetic Role on Antibody Expression From CMV Promoter and DNA Elements Flanking the CHO TI Host Landing-PadKavya Ganapathy, Andrew McKay, Steffen Durinck, et al.
Biotechnology Progress|March 6, 2023
Combining regulated and constitutive protein expression significantly boosts protein expression by increasing productivity without affecting CHO cell growthCynthia Lam, Joseph Carver, Domingos Ng, et al.
The EMBO Journal|June 30, 2007
Sequence and structure evolved separately in a ribosomal ubiquitin variantAndré Catic, Zhen-Yu J Sun, Daniel M Ratner, et al.
Biotechnology Progress|April 23, 2013
Chinese hamster ovary K1 host cell enables stable cell line development for antibody molecules which are difficult to express in DUXB11-derived dihydrofolate reductase deficient host cellZhilan Hu, Donglin Guo, Shirley S M Yip, et al.
Biotechnology Progress|February 12, 2017
Evaluation of heavy chain C-terminal deletions on productivity and product quality of monoclonal antibodies in Chinese hamster ovary (CHO) cellsZhilan Hu, Danming Tang, Shahram Misaghi, et al.
Biotechnology Progress|September 24, 2017
Beating the odds: The poisson distribution of all input cells during limiting dilution grossly underestimates whether a cell line is clonally-derived or notYizhou Zhou, David Shaw, Cynthia Lam, et al.
Journal of Biotechnology|June 12, 2020
Insulin degrading enzyme (IDE) expressed by Chinese hamster ovary (CHO) cells is responsible for degradation of insulin in culture mediaSalina Louie, Jayanthi Lakkyreddy, Brian M Castellano, et al.
Biotechnology Progress|May 10, 2023
Activation of the PERK branch of the unfolded protein response during production reduces specific productivity in CHO cells via downregulation of PDGFRa and IRE1a signalingBrian M Castellano, Danming Tang, Scot Marsters, et al.
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